Journal: International Journal of Pharmaceutics: X

Article Title: Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process

doi: 10.1016/j.ijpx.2024.100287

Figure Lengend Snippet: Model type, inputs and outputs for each process model used to develop the flowsheet model.

Article Snippet: The granule dissolution process was modelled using the ordinary differential equation (ODE) model based on the Noyes-Whitney ( ) and Nernst-Brunner ( ) equation, where the concentration balance of the bulk solute and the mass balance dissolving granule is denoted by Eq. and Eq., respectively. (19) d C b , i dt = k i C sat − C b , i = s 1 , s 2 (20) d m i dt = − k i A i C sat − C b , i = s 1 , s 2 Here, C b is the bulk concentration, C sat is the saturation concentration, k is the mass transfer coefficient, and A is the surface area.

Techniques: Dissolution